A lot of white spots on the hands may be caused by vitiligo, idiopathic hypopigmented spots, post-inflammatory hypopigmentation, etc. Patients can improve their condition through general treatment, medication and surgery. Vitiligo: patients should avoid triggering factors such as trauma, exposure to sunlight and mental stress. Vitamin D3 derivatives, such as calcipotriol ointment, etc.; glucocorticoid preparations, such as fluticasone propionate, etc.; and calcium-modulated phosphatase inhibitors, such as pimecrolimus cream, etc., may be used in transplantation treatment for patients with vitiligo in the stabilized stage. Idiopathic hypopigmented spots: patients should pay attention to skin care, avoid contact with irritants, pay attention to sunscreen, shading and so on. Generally no special treatment is needed. Post-inflammatory hypopigmentation: hypopigmented patches can be left behind after inflammation of the skin, and most of them can be restored by themselves with the prolongation of time. It is recommended that patients strictly follow the doctor’s instructions for medication, actively cooperate with the doctor’s treatment, pay attention to monitoring the condition in life, and regular review.