Itchy and painful vaginal opening may be related to condyloma acuminatum or vulvar and vaginal inflammation, such as non-specific vulvovaginitis, trichomonas vaginitis, vulvovaginal pseudomyxomatosis, allergy, and so on. 1. Condyloma acuminatum: After being infected with human papilloma virus, women may develop condyloma acuminatum at the vaginal opening, vagina, perianal area, etc. Red papules or white or pink warts appear at the lesion site, and a few of them have uncomfortable symptoms such as foreign body sensation, tingling and burning pain. 2. Vulvar and vaginal inflammation: women do not pay attention to the vaginal hygiene and local dampness and other reasons can stimulate the vaginal skin, causing non-specific vulvovaginitis, local pain, itching or burning sensation. Trichomonas vaginitis can be transmitted directly through sexual intercourse, causing vulvar itching, pain, increased vaginal discharge or pain during sexual intercourse; vulvovaginal pseudomycelium yeast disease can also have vulvovaginal itching, burning pain and pain during sexual intercourse and other symptoms. 3. Allergy: the vulva and vaginal opening may be localized to such as sanitary napkins and other allergies, manifested in the vaginal opening of the itching pain discomfort. Female perineum or vaginal pain, itching symptoms may also have other reasons, it is recommended to go to the regular hospital specialists in a timely manner, after a clear diagnosis and treatment as prescribed by the doctor.