The contraindications of ganoderma lucidum spore powder are mainly the following: First, patients who are prone to allergies are not able to eat, otherwise they will have respiratory allergies, coughing, coughing, wheezing, and even breathing difficulties, and then the patient’s skin mucosa will have edema, rash, and most seriously, laryngeal edema, which affects breathing. The second point is that ganoderma lucidum spore powder is contraindicated because it affects the digestive tract, so patients with gastritis, especially those with severe gastric ulcers, must be contraindicated from eating ganoderma lucidum spore powder to prevent inducing ulcers, bleeding or even perforation, and should be clinically alert. The third point, the contraindication of ganoderma spore powder, children eat as little as possible or do not eat. It should also be applied with caution to people with some special constitution, including those with some reactive diseases, like patients with endocrine disorders, should be contraindicated.