Osteoarthritis (OA) is a chronic, progressive joint disease that affects mainly small and large joints of the hands in middle-aged and elderly people, and its incidence gradually increases with age. Its main pathological features are degeneration and destruction of articular cartilage, followed by synovial and subchondral bone lesions. The pathogenesis of OA is not well understood by modern medicine. There is no effective treatment for this disease, and joint replacement surgery in the late stages of osteoarthritis is good for relieving pain and restoring joint function, but the cost of treatment often limits its application. Therefore, the early prevention of osteoarthritis should receive greater attention. A. Etiology of osteoarthritis of the knee Chinese medicine believes that the cause of this disease is mainly liver and kidney deficiency, chronic strain and local injury. The pathogenesis is generally based on the deficiency of the liver and kidney, and the cold and dampness, phlegm and stasis blocking the meridians are the symptoms. (A) Liver and kidney deficiency. The liver is the master of tendons and the kidney is the master of bones. The occurrence of this disease is related to the gradual decline of liver and kidney essence, tendons and bones slack, coupled with excessive exertion, injury to tendons and bones. Therefore, liver and kidney deficiency is the main internal cause of this disease. If the liver and kidney are full, the tendons are strong and the joints are smooth. In middle age, the liver and kidneys gradually become deficient, the qi and blood are insufficient, the tendons and bones lose their nourishment, the tendons are soft and bones are atrophied, or the wind, cold and dampness invade the body, making it easy to develop this disease. If the knee is traumatized, strained or damaged, the qi and blood do not run smoothly and the meridians are obstructed, resulting in the loss of nourishment of the tendons and bones and the onset of the disease. (B) Qi stagnation and blood stasis. The original strain and injury, combined with excessive exercise or improper posture, resulting in increased soft tissue injury to the knee, local stagnation of qi and blood, or long-standing illness, stagnation of qi and blood does not work and the disease develops. (C) External exposure to wind, cold and dampness. Insufficient liver and kidney, deficiency of qi and blood, wind, cold and dampness invade the knee, blocking the qi and blood and causing paralysis and pain. The idea of treating the disease before it happens is the idea of “preventing the disease before it happens and preventing the disease after it happens”, which has been summarized and perfected by ancient doctors for thousands of years in the process of preventing and subduing plague. At the same time, the advantages of treating the disease before it occurs in TCM prevention, i.e. holistic prevention and the use of resource-rich TCM to prevent diseases, emphasize that human beings are closely related to nature and should constantly adapt to the changes in the environment, enhance the internal factors of the body, improve the positive energy, and resist external evil. Chinese medicine emphasizes a holistic view of the human being as an organic whole, with the internal organs being mutually supportive and the qi, blood and fluids transforming into each other, interlocking. Chinese medicine has always attached importance to the prevention of diseases, and “prevention before illness, prevention after illness” has been an important clinical guideline in Chinese medicine for a long time. The prevention of osteoarthritis of the knee in Chinese medicine is to prevent the disease by blocking the pathways that may lead to the development of the disease. The main causes of the disease include liver and kidney deficiencies, blood stagnation and external sensation of wind, cold and dampness caused by OA, although the evidence is not out of the category of paralysis, but the patient is often old, the disease for a long time and more in the body weight or activity of the joints, so the liver and kidney deficiencies, Qi and blood deficiency, tendons and bones is the main pathogenesis of the disease, as “Zhang’s Medical General” cloud: “Knee for the tendons of the House, there is no knee pain is not The deficiency is due to liver and kidney deficiency, and the deficiency is attacked by wind, cold and dampness. Therefore, we emphasize the role of tonifying the liver and kidney and benefiting the Qi and blood in the prevention and treatment of this disease.