Lipoma is a kind of benign tumor, which usually grows slowly, and there are usually two ways of conservative treatment and surgical treatment. If the lipoma grows in the thigh and swells up a big bag, the specific treatment needs to be based on the size and growth site of the lipoma, and whether it produces compression, pain, and triggers limb disorder. 1. Conservative treatment: Generally speaking, if the size of lipoma is not too big, and there is no obvious symptom, no compression, and it does not affect limb dysfunction, conservative treatment can be considered, i.e., avoiding oily and spicy food and alcoholic beverages in daily life, consuming more fresh fruits and vegetables, taking moderate exercise, and resting regularly. 2. Surgical treatment: if the patient’s lipoma is large, grows fast, presses the local tissues and organs, affects the normal function of the patient’s limbs and aesthetics, and has pain and other discomforts, the patient needs to undergo lipoma excision, to avoid the adverse consequences. The exact size of the lipoma needs to be determined by professional doctors. When patients find lipoma swollen up in the thigh, they should go to the hospital in time to consult the doctor, and clarify the specific treatment measures under the doctor’s guidance and examination, in order to help recover as soon as possible.