The causes of generalized weakness, hot and cold are infectious diseases, menopausal syndrome, neurasthenia and so on. 1. Infectious diseases: for example, when there is an upper respiratory tract infection, acute bronchitis and other infectious diseases, due to the influence of the pyrogen, resulting in an increase in body temperature, the patient will be manifested as generalized weakness, cold and hot. 2. Menopause syndrome: female patients with the age of the body’s estrogen gradually decline, resulting in hormonal disorders in the body, the patient will be manifested as generalized weakness, hot and cold, irritability, anxiety and so on. 3. Neurasthenia: prolonged psychological stress, resulting in vegetative nerve disorders. Patients may have generalized weakness, hot and cold symptoms, accompanied by anxiety, depression, chest tightness, palpitations and so on. When the occurrence of general weakness, cold and hot symptoms, you can go to the hospital internal medicine or gynecology.