Diffuse liver disease is a more serious condition in which the liver shows diffuse liver on imaging after liver injury. Diffuse liver disease is a diagnostic term used in liver ultrasonography, and the more common causes are viral hepatitis, liver injury, steatohepatitis, alcoholic liver damage, and drug-related liver injury. Diffuse hepatitis is mainly due to the long-term replication of the virus in the liver caused severe liver damage, the liver self-repair process formed a streak of hyperplasia, fibrous tissue, and these hyperplasia will destroy the normal structure of the liver. With the prolongation of time, the condition of diffuse liver disease will gradually aggravate, if the treatment is not timely may cause liver failure, varicose vein rupture bleeding, etc., the serious will affect the patient’s life safety, so diffuse liver disease is a more serious disease, it is recommended that the patient consult a doctor in a timely manner for examination, to clarify the cause of the disease for targeted treatment, do a good job of monitoring the condition of the life, and regular review.