The three bilirubins are total bilirubin, direct bilirubin and indirect bilirubin. High triple bilirubin is mainly considered liver disease. Antiviral drugs, hepatoprotective drugs and drugs to improve bilirubin metabolism can be chosen according to the cause of the disease. During the treatment period, the medication should be strictly adhered to the doctor’s prescription and the dosage should not be changed without authorization. 1. Antiviral drugs: If the increase of bilirubin is caused by viral hepatitis, it is necessary to carry out antiviral treatment under the guidance of doctor and take antiviral drugs, such as entecavir for hepatitis B, ribavirin for hepatitis C, etc. According to the different types of hepatitis, different kinds of drugs should be chosen. 2. Hepatoprotective and enzyme-lowering drugs: Because patients suffer from liver diseases with liver function damage, they should take hepatoprotective and enzyme-lowering drugs under the guidance of doctors, such as silymarin. 3. Drugs to improve bilirubin metabolism: take drugs to improve bilirubin metabolism under doctor’s guidance to reduce bilirubin, such as adenosylmethionine. Bilirubin is high, should be standardized under the guidance of the doctor diagnosis and treatment, the drug should be used in accordance with the doctor’s instructions.