Buerger’s disease, also known as thrombo-occlusive vasculitis. It is caused by the generation of inflammatory reactions in the lumen of blood vessels due to various reasons, resulting in thrombosis, vessel blockage, lumen narrowing, and even occlusion, causing a series of clinical symptoms of arterial ischemia. It can mainly involve small and medium-sized arteries and veins, and is more common in the lower extremities. The symptoms of Berger’s disease are mainly ischemia of the lower extremities, and mild patients may show symptoms of ischemia in the distal tissues. Pain, numbness, coldness and other sensations, or abnormal movement are the main manifestations. Intermittent claudication will develop with further progression of the disease. Intermittent claudication will gradually decrease in claudication distance with the severity of the disease. Severe cases may result in inability to palpate a pulse or sensory-motor dysfunction. In advanced stages, patients may develop ulcers on the distal toes, which can lead to serious adverse consequences such as sepsis if secondary infection develops.