Whether strong positivity for HLA-I in acute leukemia affects transplantation is analyzed specifically based on the specific antibody titer and provider-specific antibodies, etc. Some strong positivity for HLA-I can affect the success rate of bone marrow transplantation.
HLA refers to human leukocyte antigens, including many antigens, and different antigen positivity is seen in different rheumatic diseases. The rate of HLA-I positivity increases with the number of transfusions and platelet concentrates given to patients with malignant hematologic disorders who are repeatedly transfused, and patients with HLA-I positivity may experience ineffective transfusion of red blood cells and platelets.
Immunosuppressive drugs, such as rituximab, may be used prior to transplantation to eliminate the antibodies and improve viability. All of the above medications should be used as directed by the physician.