Hypertrophic obstructive cardiomyopathy may increase the incidence of sudden death when the outflow tract pressure reaches a certain level (30 mmHg), so reducing the left ventricular outflow tract pressure may be valuable in relieving clinical symptoms or even the occurrence of sudden death. Pharmacologic therapy is the most preferred treatment option at present, and interventional and surgical treatment may be considered when pharmacologic agents fail to control clinical symptoms well, such as chest pain, chest tightness, severe shortness of breath, dizziness, dark haze, and syncope still exist. The ideal drug treatment is to reduce the outflow tract pressure to 50 mmHg during activity and 20 mmHg at rest. If the standard has been reached at rest, or if the symptoms are still present during exercise, an exercise stress test or drug stimulation test ultrasonography can be done to determine whether the symptoms originate from outflow tract obstruction. If the test result of outflow tract pressure is greater than 50 mmHg, interventional or surgical treatment can be considered.