The small blisters on the palm of the hand is very itchy, consider and sweat herpes, hand eczema, tinea versicolor and other factors related to the doctor’s guidance with the use of topical glucocorticoid ointment, oral antihistamine medication, topical antifungal medication for treatment. 1. Sweat herpes: small blisters on the palm of the hand accompanied by very itchy symptoms can not be ruled out as a result of sweat herpes, after diagnosis can be given to the topical tretinoin ointment treatment, if necessary, can be added to the oral loratadine, cetirizine and other antihistamines, to help alleviate the symptoms of itching. 2. Hand eczema: If the patient has hand eczema caused by infection, contact with allergens, physical stimulation and other factors, it will also cause the patient to appear fingers, palms, back of the hand and other parts of the small blisters, accompanied by itching symptoms. Under the guidance of a doctor, you can use hydrocortisone butyrate ointment and other medications, if the symptoms are more serious, you can take oral antihistamines such as loratadine. 3. ringworm: small blisters on the palm of the hand is very itchy, may also be due to ringworm factors, treatment is mainly based on antifungal, you can choose miconazole, ketoconazole, clotrimazole and other topical antifungal drug treatment. It is recommended that the patient can go to the hospital dermatology department, need to cooperate with the doctor to improve the relevant examination, to determine the cause and then do treatment and treatment, do not self-medication.