Heartburn and acid reflux may be caused by gastroesophageal reflux disease (GERD), peptic ulcer, functional dyspepsia, etc. It can be treated with medications that inhibit gastric acid, promote gastric motility, and protect the gastric mucosa, and more attention needs to be paid to interventions in daily life. 1. Gastroesophageal Reflux Disease (GERD): Patients often have symptoms such as heartburn, acid reflux and retrosternal pain. The patient can follow the doctor’s instruction to choose the medication to inhibit gastric acid, improve gastric power and protect gastric mucosa, such as omeprazole, mosapride, bismuth potassium citrate and so on. 2. Peptic ulcer: (1) Especially for those who suffer from gastric ulcer and duodenal ulcer, heartburn, acid reflux, abdominal distension, abdominal pain and other symptoms will occur. The use of drugs that inhibit gastric acid, promote gastric motility and protect the gastric mucosa, such as rabeprazole, domperidone, bismuth potassium citrate, etc., can be prescribed by the doctor. (2) However, for those who have Helicobacter pylori infection, it is necessary to give medication to remove Helicobacter pylori, i.e. a proton pump inhibitor plus a bismuth agent plus two antibiotics, and the commonly used medications include omeprazole, bismuth potassium citrate, clarithromycin, amoxicillin and so on. 3. Functional dyspepsia: patients will have heartburn, acid reflux, loss of appetite, nausea, vomiting and other symptoms, and there may be recurrent episodes. It can be treated with medicines to promote gastric motility, help digestion and protect gastric mucosa, such as domperidone, polypeptide tablets, bismuth potassium citrate and so on. In addition to medication, it is also necessary to pay more attention to the adjustment of dietary structure, quit smoking and alcohol, and for the persistence of the person, it is recommended to consult a doctor in time to clarify the cause of the disease, and under the guidance of the doctor to the cause of the treatment.