Whether lupus nephritis can be completely cured mainly depends on clinical symptoms, pathologic type, treatment effect and other factors. If the patient’s clinical symptoms and pathologic type are mild and the treatment effect is good, lupus nephritis may be completely cured; if the patient’s clinical symptoms and pathologic type are severe and the treatment effect is poor, the condition may gradually progress to chronic renal insufficiency, which cannot be completely cured at this time. Lupus nephritis is the kidney damage of SLE. About more than 50% of SLE patients have clinical manifestations of kidney damage, and kidney biopsy shows involvement of almost >100%. Lupus nephritis is one of the major causes of end-stage renal failure in China. The renal manifestations of lupus nephritis vary widely. If the patient’s clinical symptoms and pathological types are mild and the treatment effect is good, lupus nephritis may be completely cured; if the patient’s clinical symptoms and pathological types are heavy and the treatment effect is poor, the condition may gradually progress to chronic renal insufficiency and irreversible damage occurs, and at this time, it can not be completely cured. Patients with lupus nephritis are advised to go to regular hospitals in time for consultation and targeted treatment or therapy under the guidance of doctors.