“Doctor, my progesterone level is only 20, yesterday it was 30, why has it dropped today …… doctor, the progesterone level is less than 10, am I afraid? …… they said my estrogen is too low, could it be that I didn’t get laid? …… why her HCG is over 800 and mine is only 200, is it biochemical ……” During the usual outpatient consultation and Q&A on the WeChat platform, people like to ask questions about the blood draw values of various hormones. There are three reasons for this: firstly, the blood values are often not within the reference range or even exceed the upper limit by a lot; secondly, their own values fluctuate several times before and after and they are worried that the changes in blood values may have adverse effects on the transplantation; thirdly, all the enthusiastic sisters and sisters secretly compare themselves in private and their hearts fluctuate with the high and low blood values, and they are afraid when they are high and frightened when they are low, and finally they can only go to the doctor to ask for a fair statement. This has a conventional consultation questions, each showing entanglement: “Doctor, my progesterone value is only 20, yesterday 30, how to drop today …… doctor, progesterone value is less than 10 afraid of …… they said my estrogen I’m not sure if it’s too low, could it be that I didn’t get laid …… why her HCG is more than 800 and mine is only 200, is it biochemical ……” Please take it easy, I’m going to fix your mind. First of all, please do not compare the results of blood draws with other sisters. Do not compare this truth in life who understands, why, because everyone is different, just like the world is not the same two leaves. Even if you and she are the same age, height and weight, the medication regimen, body metabolism and drug reactions are hardly the same, so comparing is not beneficial, but affects the mood of each. So, the first thing you should do when you get your results is to go through the fast track clinic and ask your doctor to analyze them for you. After you have stabilized your emotions, please listen to me again about how to look at the blood draw results after the transplant. Generally, our center recommends that you have your estradiol (E2) and progesterone (P) checked on the day of transfer, four days after the transfer and on the day of pregnancy test. The main purpose of this is to be able to guide and adjust your medication to further improve your success rate. Please note: The transfer blood draw results for fresh and frozen embryo transfer cycles are completely different! Fresh cycles undergo ovulation promotion, many follicles grow together, there are many corpus luteum after egg retrieval, and the production of estradiol and progesterone is much higher than in natural or hormone replacement cycles, so the post-transfer blood draw results of fresh embryos are often high, which is also correlated with the number of eggs retrieved and the medication used after transfer. If estrogen rises rapidly after the transfer, your doctor will further evaluate you for symptoms of ovarian hyperstimulation and adjust your medication afterwards. If your post-transplant estrogen drops rapidly, from a few thousand to a few hundred, it may indicate that your body is not producing enough luteinizing hormone and your doctor may also give you additional luteinizing support medication. If it is a small fluctuation, it is related to the time of blood draw after medication as well as the standard deviation inherent in the measurement, so please don’t worry about it and go home with peace of mind. When I hear people spreading rumors lately about the correlation between high and low estradiol and fetal heartbeat, etc., I just have to shake my head and sigh in amazement at everyone’s imagination. With regard to progesterone values, people seem to show a higher level of concern that its high or low level has more to do with pregnancy. In fact, the progesterone value is closely related to the dosage and dosage form of progesterone support. For example, sisters who take intramuscular progesterone have higher blood draw values, usually above 10, while manual cycles (one of the protocols for preparing the lining in frozen cycles) are usually below 10 if only plugging (Angiotensin or Xanadu) and taking oral Duffetone. This is because the progesterone from intramuscular injections is able to get into the bloodstream, so it can be reflected in the blood draw values. If you just plug the pill or take it orally, your doctor will give you enough and you won’t have to worry about a single-digit progesterone value. The HCG value is the focus of comparison. Some of my sisters kept rechecking their HCG during the first few months of early pregnancy and came to visit me nervously every few days. I am certainly happy to see you pregnant, but there is really no need for repeated rechecking. If your doctor is concerned about your blood draw on the day of your pregnancy test, he or she will recommend that you retest your HCG after 3 days of continued medication to determine the progress of your pregnancy by whether it has doubled. If the HCG is below 100 on the day of the pregnancy test and the HCG drops significantly on the retest, a biochemical pregnancy is likely. If the HCG only rises on the retest, your doctor will also alert you to the possibility of ectopic pregnancy and even recommend hospitalization for observation if you have symptoms. If the HCG is high on the day of the pregnancy test, the risk of twin pregnancy is also increased. Of course, the fact that the blastocyst pregnancy test HCG value is usually higher than on day D3 should also be taken into account. The second and more important thing is that comparison will increase your anxiety and nervousness. The saying “people are more angry than others” is an exaggeration, but this bad comparison will really do no good. I hope everyone can do not compare, not tangled, happy every day after transplant!