There are several kinds of medicines for anal fissure: 1, external medicines. Nitroglycerin ointment can be applied externally to the anal fissure, which can reduce the pressure of the anal canal and relieve the pain caused by spasm of the sphincter, as well as erythromycin ointment, Jiuhua ointment, Ma Yinglong hemorrhoidal ointment, etc. Hemorrhoidal suppositories can be used to have anti-inflammatory, analgesic and hemostatic effect of the anus tai suppository or taining suppository. 2, fumigation medication. You can use 1:5000 potassium permanganate solution with anti-inflammatory effect, with the role of heat detoxification and dry dampness toxin-expelling soup lotion. 3, oral medication. Patients with constipation can take oral laxatives, such as Ma Ren Pills, lactulose and so on. If the effect of drug treatment is not good, has developed into old anal fissure, can take the method of surgical treatment.