Piriformis syndrome lying leg pain can be applied to drug treatment, physical therapy. Pearly muscle syndrome lying leg pain, considering the local nerve compression is obvious, the nerve root edema, can be combined with drug treatment, the application of non-steroidal painkillers, such as diclofenac sodium extended-release tablets, but also the application of the treatment of neuralgia drugs, pregabalin. Oral blood-activating and pain-relieving medications, such as Shujiweiqi tablets. Topical application of musk pain relief cream can also be used. Physical therapy, such as deep heat therapy or ultrasound physiotherapy, can play an anti-inflammatory and analgesic effect, and local acupuncture can also be performed. Most of the above methods can be relieved, if there is no relief need to go to the hospital for treatment. The above drugs should be used under the guidance of a doctor, avoid self-medication.