The most common disease that causes spots on the face due to staying up late is chloasma, whose onset is related to ultraviolet rays, endocrine disorders and other factors, which can be improved by improving lifestyle, medication and medical treatment. 1. Improve life style: Regular work and rest, avoid staying up late and overwork, and ensure sufficient sleep time. Eat a well-balanced diet and avoid stress and anxiety. Pay attention to skin care, sun protection and cleaning. Avoid using spot removal products by yourself. 2. Medication: Hydroquinone cream, azelaic acid cream, vitamin A acid cream and other medicines can be used to relieve hyperpigmentation, and vitamin C and vitamin E can be taken orally to inhibit melanin synthesis and antioxidant. 3. Medical treatment: laser, intense pulse light and mesotherapy can be used to improve chloasma symptoms. If you stay up late and have spots on your face, it is recommended that you consult a doctor in time and choose reasonable treatment under the guidance of the doctor, and follow the doctor’s instructions for medication to avoid adverse reactions.