Epilepsy is caused by brain dysfunction, and the most common form of seizure is generalized twitching, so many people mistakenly think that epilepsy is equal to convulsive disease. In fact, besides generalized twitching, epilepsy has many other seizure forms, such as transient apoplectic seizures and psychomotor seizures, and the medication used in treatment is different. As early as B.C., several famous physicians pointed out that epilepsy is prone to seizures during sleep, especially generalized convulsive seizures. This argument has remained true until modern times, so that in the diagnostic steps for epilepsy, physicians often include a recommendation for a “sleep-induced EEG”, stating that a routine awake EEG is not sufficient and that an EEG must be done after the patient has fallen asleep to make the diagnosis more definitive. Why is it easier to diagnose epilepsy during sleep? We already know that the EEG during sleep reveals non-rapid eye movement phase sleep (NREM) and rapid eye movement phase sleep (REM), whereas epilepsy has specific waveforms, medically known as spikes and spikes, and these are small, fast and transient waves. If spike or sharp waves are present on the EEG, the physician can safely diagnose the patient as having epilepsy. Some scientists have now discovered that when epileptic patients fall asleep, they often have paroxysmal activity during NREM, interspersed with spike or sharp waves, especially more pronounced in phases III and IV of NREM. Why does this phenomenon occur? The scientists’ explanation is that the feedback pathways in the thalamocortex are strengthened and often volatile during sleep in epileptic patients, so that they show up on the EEG as paroxysmal activity interspersed with spikes or sharp waves. The news is not that epileptic patients are not allowed to sleep to prevent seizures, but that patients should be aware that seizures are easy to occur during sleep, so the medication technique should be adjusted appropriately, such as you do not have to take medicine three times a day, one tablet each time, in the morning, noon and afternoon, can you change it to morning, noon and evening? Or change it to one tablet in the morning and two in the evening? This would increase the amount of medication during sleep and give you enough power to control the seizures. Interested readers may want to give it a try!