Vulvar leukoplakia generally refers to white lesions of the vulva, and vitamin 12 mostly refers to vitamin B12.Vitamin B12 does not treat white lesions of the vulva. Vitamin B12 is indicated for megaloblastic anemia, subacute combined degenerative neurological lesions, and generally does not treat vulvar leukoplakia. Adverse reactions such as rash and itching may occur in some people with the use of this product. People who are allergic to this product and patients with glaucoma should use it with caution. Vulvovaginal leukoplakia refers to a disease in which the skin and mucous membrane tissues of the vulva of women are altered in pigmentation. Patients are advised to follow the doctor’s instructions to use topical tretinoin, hydrocortisone and other glucocorticoid drugs, which have anti-inflammatory and anti-itching effects. For patients for whom conservative treatment is ineffective, surgical excision is recommended to help alleviate the disease. Vitamin B12 is generally unable to treat vulvar leukoplakia, it is recommended that patients go to a regular hospital, cooperate with the doctor for standardized treatment, avoid unauthorized use of drugs.