There is no best match for Bisoprolol, and it is important to choose the right match drug based on the patient’s condition. Bisoprolol’s main role is to inhibit the body’s beta receptors, the main effect is to lower blood pressure, reduce myocardial oxygen consumption, can be used for hypertension and coronary heart disease patients. For bisoprolol lowering effect is not good for patients with hypertension, and other drugs can be used in combination, there is no best match, to give patients the most appropriate match. Patients with coronary artery disease combined with hypertension, bisoprolol can be used in combination with amlodipine, lowering blood pressure at the same time can increase the blood supply of coronary arteries. Patients with cardiac insufficiency, bisoprolol can be used in combination with valsartan, which has a protective effect on the heart. Bisoprolol’s adverse reactions include cold extremities, bradycardia, hypotension, dyspnea, nausea, dizziness, etc. It is contraindicated in patients with allergy to the drug components, bronchial asthma, cardiogenic shock, severe bradycardia, and second-degree and third-degree atrioventricular block. Bisoprolol is used in combination with other drugs under the supervision of a physician.