The therapeutic effect of hexoketone cacodylate on membranous nephropathy is mainly reflected in its ability to reduce renal damage by inhibiting the synthesis of TNF-α, and then reduce renal damage; it may also improve microcirculation and treat membranous nephropathy combined with peripheral vasculopathy and so on. Membranous nephropathy is an immune-mediated glomerular disease that consists of the formation of immune complexes by the specific binding of antigen and antibody, followed by the activation of complement, a process that can lead to the elevation of tumor necrosis factor (TNF-α). Hexoketone Cocaine can reduce and inhibit the synthesis of TNF-α and reduce its damage to renal tissues. Membranous nephropathy is often combined with complications such as thrombosis and embolism, commonly seen in lower extremity venous thrombosis, renal venous thrombosis and pulmonary embolism. Hexetone cocaine is a non-specific peripheral vasodilator, and its metabolites have the effect of improving blood viscosity and microcirculation, which in turn plays a certain therapeutic role. It should be noted that the drug specification mentions that hexetocaine is mainly used to improve cerebral circulation after ischemic stroke, and can be used in peripheral vascular disease, but does not mention that it can treat membranous nephropathy. Therefore, patients with membranous nephropathy need to follow the doctor’s instructions to take this drug, not self-medication, pregnancy, patients with a history of allergies should be used with caution.