The ectodermal dysplasia syndrome is also known as Ellis-vanCreveld congenital malformation syndrome, congenital calcification disorder heart disease syndrome, ectodermal dysplasia syndrome and other health searches, as autosomal recessive disorders snipe, manifesting as short-limbed dwarf snipe, often with congenital heart disease and mental retardation. The newborn infant appears to be a dwarf, such as short and thick long bones, small distal fingers (toes), and multiple fingers (toes), poorly developed hair and teeth, and incomplete calcification of the long bone epiphysis of the whole body. What can cause the calcification insufficiency of the long bone epiphysis? It is not well understood and is thought to be related to the abnormal formation of the ectodermal lobe during the embryonic period. It may be due to impaired nutrient uptake in the ectodermal lobe. The result is a dwarf appearance at birth, characterized by hypoplastic cartilage, polydactyly, hypoplastic ectodermal tissue, which affects the growth of hair, teeth, and nails, as well as the possibility of predisposing congenital developmental abnormalities such as congenital heart disease. Patients are born with a dwarf appearance, characterized by chondrodysplasia, polydactyly, ectodermal tissue dysplasia, affecting the growth of hair, teeth, and nails, and the development of congenital heart disease. Chondrodysplasia is characterized by shortening of the long bones of the upper and lower extremities, with the distal segments being more severe than the proximal segments, so that the long bones below the knee and elbow are shorter. It has little effect on the trunk, so it forms a dwarf. The proximal end of the tibia is dilated and pointed, and the epiphysis is poorly developed and slides medially. There are bony warts protruding from the medial side of the proximal tibial epiphysis, the fibula is short, and unlike chondrodysplasia, the lower leg shows knee valgus and the patella is displaced outward at the same time. The radial head is often dislocated and the phalanges are very short due to the absence of ossification centers in the phalanges. The wrist bone and ulna and radius can be fused; the femur and humerus are bow-shaped, short and thick; the rib cage is short, so the thorax can be long and narrow. The skull is normal. Polydactyly is a typical feature, mostly seen on the ulnar side, and radial polydactyly is less common. Ectodermal tissue dysplasia is manifested by hypoplastic nails, which are small, spatulate and concave on the dorsal side. The teeth are late to erupt, irregular, cusp-shaped, and have poor occlusion. The maxillary gingival pads are fused. The gingivolabial sulcus of the upper lip is closed. There is also baldness, etc. Mesodermal defects manifest as congenital heart disease, commonly atrial septal defect or ventricular septal defect. Mitral valve stenosis and the heart may be 3 or 2 chambers. Patients have normal intelligence and sometimes other malformations such as undescended testes and cleft palate may be present. The main shortening feature of this disease is caused by shortening of the tibia and fibula below the knee and the ulna and radius far from the elbow. Therefore, it is generally not difficult to differentiate based on clinical appearance and X-ray examination.