When advanced cancer patients have fever, different fever reducing methods should be adopted according to different reasons. The cause of fever in advanced cancer patients may be tumor fever. If the body temperature is lower than 38.5℃, physical cooling methods such as warm water on forehead and whole body bath can be used to reduce fever, and more water should be drunk to help reduce the body temperature. If the body temperature is more than 38.5℃, you can take oral antipyretic drugs, such as day and night Benadryl, Merlin, etc. At the same time, ice pack should be applied to forehead to protect the brain. More frequent cause of fever in advanced cancer patients is infection. The most effective way to reduce fever at this time is to apply effective anti-inflammatory treatment with antibiotics. Before applying antibiotics for anti-inflammatory treatment, it is better to do a blood culture, i.e. to take the patient’s blood for bacterial and fungal culture, so as to choose more effective antibiotics according to the cultured bacteria. When the body temperature exceeds 38.5℃, take antipyretic drugs orally and apply an ice pack to the forehead at the same time to protect the brain, or you can combine physical cooling methods to bring down the body temperature as soon as possible. No matter what causes the fever, the most fundamental treatment is to control the growth and spread of tumor, only this can finally eliminate the fever.