There is no such thing as the fastest solution for generalized itch. Generalized itch needs to be treated according to the cause. If it is caused by allergic factors (such as hives, etc.), it can be treated by avoiding contact with allergens, general treatment and medication; if it is caused by diabetes leading to peripheral nerve sensation, it can be treated by actively treating the primary disease (controlling sugar, improving diet, etc.), and symptomatic treatment and other methods. 1. Allergic factors: most of the itching in the whole body is seen in urticaria, which is caused by allergic factors. First of all, we need to try to avoid contact with allergens, usually should avoid spicy and stimulating food, pay attention to personal hygiene; can be under the guidance of the physician oral levocetirizine tablets, prednisone acetate tablets, external glycerine lotion and other medicines to treat. 2. Diabetes causes peripheral nerve sensory abnormalities: diabetes due to insulin secretion due to insufficient blood glucose control can appear after the peripheral nerve sensory abnormalities and lead to itching. Oral metformin tablets, subcutaneous injection of insulin and other drugs under the guidance of a physician, low-salt, low-fat, low-sugar diet; severe itching can be oral loratadine tablets and other anti-allergy drugs to relieve. It is recommended that patients go to the hospital for consultation, after a clear diagnosis of the cause of the disease, follow the doctor’s instructions for targeted treatment, do not self-medication.