Mr. Yan is 71 years old, eight months ago, began to cough, cough sputum, sometimes accompanied by fever symptoms, think it is a common cold did not pay much attention to, take antibiotics on their own to treat the symptoms can be alleviated or control, but can not be cured, always recurring, after the situation aggravated, found that began to stifle wheezing, coughing up phlegm, and sputum with blood, rushed to the local hospital for medical treatment, chest CT examination, found that the main lower part of the windpipe He was referred to our hospital for further treatment. After admission, the patient was examined by bronchoscopy under general anesthesia, and a space-occupying lesion in the lower part of the trachea near the rump was seen under the bronchoscope, which was about 3 cm in length and blocked more than 80% of the main airway. The mass was then removed by a combination of argon knife and carbon dioxide cryotherapy. The patient’s breathing was relieved immediately after the operation because of the difficulty. Lesson: Early symptoms of central airway obstruction are coughing and difficulty in breathing, while in the middle and late stages, symptoms such as wheezing and blood in sputum may occur, which can be solved by bronchoscopic intervention. Before treatment, 80% of the main airway obstruction was removed after treatment, and the lumen was opened.