High LDL is seen in coronary heart disease, hypothyroidism, cholestatic jaundice, obesity, nephrotic syndrome, etc., which requires drug treatment and surgery. 1. Coronary heart disease: it is positively correlated with the level of LDL, and it should be taken lipoprotein-lowering drugs such as atorvastatin. 2. Hypothyroidism: mainly thyroxine replacement therapy, such as taking levothyroxine, which requires lifelong medication to restore the serum thyroxine to the normal range. 3. Cholestatic jaundice: medications can be taken to relieve symptoms, such as kala-enanthine to relieve skin itching; surgery can be performed to remove choledochal stones that cause obstruction. 4. Obesity: adjust the diet, carry out scientific exercise, reduce weight. 5. Nephrotic syndrome: mainly hormone and cytotoxic treatment, such as glucocorticoid. 6. Application of androgens and beta-blockers: reduce the dosage or stop using them. For diseases that cause high LDL in addition to actively treating the primary disease, but also to take lipoprotein-lowering drugs such as pravastatin, etc., you should consult a doctor in a timely manner, under the guidance of a professional physician to choose the appropriate treatment.