Itching on the body in the middle of the night may be caused by dry skin, allergic reactions, mosquito bites, scabies and other reasons. 1. Dry skin: If you usually over-wash, it may lead to a decrease in the lipids on the surface of the skin, causing dry skin and itchy skin, especially at night when the itch is more pronounced. 2. Allergic reaction: may also be allergic to bed sheets, covers and other bedding caused by, especially in contact with the polyester fiber containing the composition of the bed sheets, covers, may be prone to cause itchy body at night. 3. Mosquito bites: at night when sleeping, if the mosquito bites the skin, it will easily lead to insect bite dermatitis, the phenomenon of itching in the middle of the night. 4. Scabies: If you suffer from scabies, your skin will itch intensely at night, accompanied by blisters, red papules and other symptoms. Itching symptoms in the middle of the night, you should go to the hospital dermatology consultation, clear cause of the disease under the guidance of the doctor to give the correct treatment and therapy.