The difference between Rosuvastatin and Atorvastatin mainly lies in the indications of the drug, adverse effects, and the time for the drug to take effect. 1. Drug indications: both drugs can be used for the treatment of primary, pure familial hypercholesterolemia and other diseases. Atorvastatin can also be used for the treatment of coronary heart disease or coronary heart disease and other critical conditions combined with hypercholesterolemia, but Rosuvastatin does not have the above indications. 2. Adverse reactions: Usually after the use of Rosuvastatin may appear itching, rash, urticaria, angioneurotic edema and other adverse reactions. While atorvastatin may have adverse reactions such as liver enzyme abnormalities, rhabdomyolysis and myopathy after use. 3. Drug effect time: Resuvastatin can reach the peak blood concentration 5 hours after oral intake, thus exerting the drug effect. Atorvastatin can reach the peak blood concentration in only 1~2 hours after oral intake, thus exerting the effect of the drug. All of the above medications should be used under the guidance of a doctor, avoid self-medication to avoid adverse consequences.