Efficacy: Anti-emetic; 1. used in chemotherapy, radiotherapy, surgery, cranial injury, post-traumatic brain injury, sea and air operations and drug-induced vomiting; 2. used in the symptomatic treatment of nausea and vomiting symptoms in various diseases such as acute gastroenteritis, biliary pancreatic, uremia; 3. used before diagnostic duodenal intubation to help smooth intubation; gastrointestinal barium X-ray examination, can reduce nausea and vomiting reaction, and promote the passage of barium. Promote the passage of barium. Contraindications: Allergic to procaine or procainamide; Seizure frequency and severity can be increased by the drug; Gastrointestinal bleeding, mechanical intestinal obstruction or perforation can be aggravated by the increased dynamics of the gastrointestinal tract; Pheochromocytoma can develop hypertensive crisis by the drug; Cannot be used in breast cancer patients who vomit due to chemotherapy and radiotherapy (long-term use can lead to hyperprolactinemia, except for breast cancer) It should not be used and should not be used by women who are preparing for pregnancy, as it can lead to infertility.) Use with caution in the following cases: hepatic failure with loss of ability to bind protein; renal failure, i.e. severe chronic renal failure, which can increase the risk of extrapyramidal reactions and the dosage should be reduced. Adverse reactions are: 1. drowsiness, irritability, fatigue and weakness; 2. rare adverse reactions are: mastalgia, nausea, constipation, rash, diarrhea, sleep disturbance, dizziness, severe thirst, headache, easy agitation; 3. increased lactation during administration, due to stimulation of prolactin; 4. injectable administration may cause upright hypotension; 5. high dose long-term application may be due to blockade of dopamine receptors, the 5. Long-term application of large doses may cause extrapyramidal reactions (especially in young people) due to blockade of dopamine receptors and relative hyperactivity of cholinergic receptors, which may result in myalgias, dysphonia, ataxia, etc., and may be treated with anticholinergic drugs such as benzhexol. The incidence of extrapyramidal reactions is significantly reduced if the dose is controlled to less than 30 mg daily for a short period of time. Parkinson’s syndrome-like symptoms such as increased muscle tone, dull face, slow movement, muscle tremor, salivation; acute dystonia with forced mouth opening, tongue extension, sloping neck, respiratory dyskinesia and dysphagia; inability to sit still, fidgeting and repeated wandering; delayed dyskinesia with mouth – tongue –The triad of cheek, such as sucking, tongue licking, chewing, etc., is known as extrapyramidal reactions. Other drugs that can cause extrapyramidal reactions are: domperidone, cimetidine, nifedipine, and rifampin.