Itchy urethra is recommended to eat macrolide antibacterial agent with better effect, the representative drugs are roxithromycin, doxycycline, clarithromycin, minocycline, these drugs can effectively treat urinary tract infection. For urethral itch, the most worry is non-gonorrhea infection, non-gonorrhea infection by oral cephalosporins or quinolones are not effective, while macrolides are effective for general urinary tract infection and very good for non-gonorrhea infection treatment. It is generally recommended to take azithromycin 0.5g orally once a night for 7-10 days to achieve clinical cure; at the same time, it is recommended to drink more water and urinate more, and it is recommended to clean the urethra effectively every day.