Multiple ischemic degenerative foci in the brain are imaging manifestations usually found during cranial CT or MRI and are mainly associated with atherosclerosis. Ischemic foci are imaging manifestations due to chronic hypoxia in the brain, usually detected by cranial CT or MRI, and may be clinically asymptomatic or may present with symptoms of chronic ischemia in the brain, such as dizziness and memory loss. The main reason for the occurrence of ischemic foci is atherosclerosis. The occurrence of atherosclerosis is usually associated with numerous risk factors, such as smoking, hypertension, hyperlipidemia, diabetes mellitus, obesity, mental stress, sleep and so on. Related risk factors should be controlled in general to avoid the occurrence and progression of atherosclerosis, thus preventing further progression of ischemic foci in the brain. When ischemic foci in the brain are detected, prompt medical consultation is recommended.