Small blisters on the hands which are very painful may be due to burns, friction, herpes and other factors, and can be given scald medication, anti-infective drugs, anti-viral drugs, as well as painkillers for treatment. 1. Scald: some patients may be because of the hands accidentally burned by hot water, thus the symptoms of small blisters, at this time can be given scald medicine for treatment, such as silver sulfadiazine cream, recombinant human epidermal growth factor gel, etc., to promote local recovery. 2. Friction: for people who often carry out hand activities, may be due to the factor of friction, thus appearing on the hands of small blisters symptoms, after the blisters burst, can be given to fusidic acid, mupirocin and other anti-infective ointment coated, to prevent the phenomenon of infection. 3. Herpes: If the patient has small blisters caused by herpes virus infection on the hands, because it is a viral infection, you can cooperate with the doctor to choose acyclovir, ganciclovir ointment to smear, when the pain is more serious, you can choose to take oral pregabalin and other medications to relieve pain treatment. If the small blisters on the hands of the patient is very painful, and the symptoms are not relieved, or accompanied by other symptoms, you should go to the hospital in a timely manner, to clarify the cause of the targeted treatment.