Diffuse changes in the thyroid gland are mainly seen in the ultrasound report of the thyroid gland, which refers to abnormal changes in the entire thyroid gland, mostly due to inflammation. It is only through these combined determinations that the specific cause of the disease can be determined, whether hyperthyroidism or hypothyroidism exists, and then targeted treatment can be given. Diffuse changes in the thyroid gland are the result of ultrasound as opposed to localized changes in the thyroid gland, such as nodules or tumors.