The appearance of small rice-like bumps on the scrotal skin of a patient may have multiple etiologies. If the patient does not have obvious pain, itching and other uncomfortable symptoms, it is considered that it may be caused by epidermal fatty grains of the scrotum, which is a benign skin lesion and generally does not require special treatment because it is not contagious and the possibility of lesions is extremely low. In addition, the following diseases cannot be ruled out: 1. Sebaceous ectopia: often occurs in the male scrotum, glans and female labia and other parts of the genital organs, with rice-sized papular skin damage as the typical symptom, without the need for special means of treatment. If patients have a large range of lesions, they can be treated by physical means such as laser, electrocoagulation, freezing, etc.; 2. Skin allergy: mainly caused by underwear friction, woolen fabrics or chemical substance stimulation, etc. Patients can have small rice-grain-like bumps at the scrotum, usually with intense itching, and the symptoms of lesions show significant expansion when scratched. The first application of topical medication such as tincture of ghost toxin, imiquimod cream, if the symptoms worsen or affect the appearance, you can choose physical or surgical methods to remove; 4, folliculitis: vagina near the hair is more exuberant, easy to breed bacteria, and in the case of impermeable underwear, improper cleaning, sweating, can induce bacterial infection, resulting in folliculitis. Patients have red bumps near the scrotum and are accompanied by itching, pain and other uncomfortable symptoms. Treatment should include ichthyolipid ointment, mupirocin ointment, and anti-infection medications such as azithromycin and cefdinir, as requested by the doctor. If the patient’s folliculitis has developed into a larger boil, surgical treatment is required; 5. Sebaceous cyst: bacterial infection, metabolite buildup, etc. cause blockage of the sebaceous ducts, which in turn results in small, movable rice-like bumps, and patients often have a series of uncomfortable reactions such as swelling, redness, and pain at the affected area. Antibiotics may be used for antibacterial treatment or surgical removal of cysts; 6. Scrotal eczema: confined to the skin of the scrotum, the patient has patches of small bumps with thin scabs and scales at the lesions. Oral medications such as chlorpheniramine maleate tablets and ketotifen fumarate tablets should be used to relieve the itchiness under the guidance of a doctor, and boric acid solution and lead acetate solution can also be used topically to treat the lesions.