A painful lump in the groin is usually considered to be enlarged lymph nodes or an extra-abdominal hernia or folliculitis, and it is recommended to clarify the cause of the disease in time and receive standardized treatment for the cause. 1. Lymph node enlargement: when the body occurs infectious diseases, inflammatory factors will stimulate the lymph nodes to cause lymph node enlargement pain, need to use antibiotics such as penicillin, tetracycline, roxithromycin, azithromycin and other medications to control the infection, the drug should be strictly in accordance with the doctor’s instructions to use. 2. Extra-abdominal hernia: due to the abnormality of the abdominal wall structure causes the abdominal contents to protrude into the abdominal cavity, when obstruction or incarceration occurs, painful lumps can be formed in the groin, which requires timely surgical treatment of the disease to restore the normal structure of the abdominal wall. 3. Folliculitis: folliculitis can be caused by bacterial infection, with pain or itching when inflammation is severe, it is recommended to follow the doctor’s instructions for topical antibiotic ointment, such as fusidic acid ointment and other anti-infective treatment. There may be other reasons for the pain in the groin, it is recommended to go to the hospital in a timely manner, after a clear diagnosis under the guidance of the doctor symptomatic treatment, do not take care of yourself.