Amoxicillin allergy can be replaced with macrolides, antibiotics from the quinolone group, etc. Amoxicillin is a penicillin broad-spectrum antibiotic, if you are allergic to the drug, the use of which may cause allergic reactions such as rash, itching; in severe cases, it may even lead to anaphylactic shock; therefore, a skin test should be done before the use of the drug, and it is prohibited to use it in positive cases. In case of amoxicillin allergy, macrolides, quinolones, cephalosporins and other types of antibiotics can be considered as alternatives. 1. Macrolides have antibacterial effects on some gram-negative bacteria, most gram-positive bacteria, mycoplasma, chlamydia, etc., and can be used for infections caused by them, such as urinary tract infections, respiratory tract infections, and skin and soft tissue infections. Commonly used such as erythromycin enteric-coated capsule, roxithromycin, acetylspiramycin and so on. The common adverse reaction of this product is gastrointestinal discomfort. Contraindication is prohibited for those who are allergic to it. Caution should be exercised against hepatic and renal insufficiency, pregnant and lactating women. 23. Antibiotics of quinolone class, common such as levofloxacin, ofloxacin, ciprofloxacin and so on. If amoxicillin allergy, to immediately stop using the drug, under the guidance of a physician to choose a drug alternative, not self-medication, so as not to cause adverse reactions.