Different antihypertensive drugs achieve antihypertensive effect through different antihypertensive mechanisms. The first-line antihypertensive drugs currently used in clinical practice have different antihypertensive mechanisms: 1, diuretics are used to reduce peripheral resistance and antihypertensive effect through sodium excretion and reduction of extracellular blood volume.2, β-receptor antagonists are used to lower blood pressure through inhibition of sympathetic excitability, inhibition of myocardial contractility and slowing down of the heart rate.3, calcium channel blockers are used to lower blood pressure through blocking of the L-type calcium channels and reduction of extracellular calcium ions into the vascular smooth muscle.4, angiotensin converting enzyme inhibitors are used to lower blood pressure through inhibition of circulatory and tissue contraction responses. Calcium channel blockers play a role in lowering blood pressure by blocking L-type calcium channels, reducing the entry of extracellular calcium ions into the vascular smooth muscle, and lowering the contraction response of the resistance vessels.4 Angiotensin-converting enzyme inhibitors play a role in lowering blood pressure by inhibiting angiotensin-converting enzyme in the circulating tissues and tissues, which reduces the production of angiotensin, and inhibiting the kinase enzyme, which reduces the degradation of bradykinin. Angiotensin II receptor antagonist, antihypertensive effect is through the blockade of tissue angiotensin II receptor, blocking the angiotensin II vasoconstriction, sodium retention and remodeling of the role of angiotensin II, so as to reduce blood pressure.