Closed-cell pimples are mainly caused by acne, and their possible causes are the accumulation of keratinized cells that clog pores. It is recommended that people who have a large number of whiteheads that remain for a long period of time visit a hospital and receive regular treatment, including medication and other treatments. 1. Medication. All medications should be used under the guidance of a doctor, and if there is any discomfort during the use of medication, it is necessary to consult a doctor in a timely manner. (1) Chemical peeling drugs: used externally on acne-prone areas, they can reduce the accumulation of keratin and promote the smooth flow of pores, so that sebum can be discharged smoothly, thus improving closed mouth acne, such as fructose, salicylic acid, and so on. (2) Vitamin A acid drugs: have the effect of inhibiting cellular keratinization and proliferation and reducing sebum secretion, including oral vitamin A acid, topical vitamin A acid cream, and so on. (3) Antibiotics: can get rid of, prevent infection, such as clindamycin, minocycline and other drugs. (4) Benzoyl peroxide: with bactericidal ability, it can kill the possible presence of Propionibacterium acnes and reduce oil secretion, thus relieving the symptoms, such as benzoyl peroxide lotion, gel and so on. 2. Other treatments: including red and blue light therapy, photodynamic therapy, acne removal, etc., all of which can help relieve symptoms, sterilize the bacteria and inhibit sebum secretion.