A tingling sensation after topical treatment with acyclovir for herpes zoster may be related to a local adverse reaction and usually resolves on its own when the medication is discontinued. Acyclovir is a commonly used medication for the treatment of herpes zoster and herpes simplex and has anti-infective properties. Common adverse reactions following the use of this medication include a mild tingling or burning sensation at the site of application, localized itching of the skin, and rash. Mild cases usually require no special intervention and return to normal with the end of treatment. Severe or extensive burning sensation, itching, redness and swelling should be stopped immediately, the medication should be washed off what has been applied, and a visit to the hospital should be made, requiring termination of the medication if necessary. It should be noted that in the treatment with the drug, if the symptoms are not effectively controlled for more than a week, it is necessary to change the drug regimen. The drug is contraindicated in cases of drug allergy, mucous membranes of the eyes, nasal passages and other mucous membranes. Women during pregnancy and lactation need to use the drug with caution. Prompt medical attention is recommended for the appearance of shingles, and acyclovir needs to be used under the supervision of a clinician.