What are the causes of hypertension after kidney transplantation? How to treat it?

The incidence of hypertension in post-transplant patients is high. In the era of immunosuppressive therapy with azathioprine as the mainstay, the incidence of post-transplant hypertension is about 50%-60%; in the era of immunosuppressive therapy with cyclosporine A as the mainstay, the incidence of hypertension is about 75%. The causes of hypertension after kidney transplantation are various, weight gain is an important reason, the transplanted kidney itself causes include: acute rejection, chronic rejection, transplanted kidney glomerulonephritis and hypertensive donor kidney, etc.; the causes outside the transplanted kidney include: transplanted kidney artery stenosis, original kidney disease, cyclosporine A or Pulcolocort (FK506) and corticosteroid drugs caused by Side effects. The treatment of hypertension after kidney transplantation is currently mainly calcium channel blockers, α-blockers, β-blockers, and in case of unsatisfactory results, angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor antagonists can be added cautiously, but attention should be paid to monitoring renal function and blood picture to avoid causing anemia and renal function damage. It is not recommended for hypertension caused by renal artery stenosis. For hypertension caused by renal artery stenosis in the transplanted kidney, interventional treatment with percutaneous vasodilation and stent placement is recommended. Severe hypertension due to primary renal disease can be treated by surgical removal of the primary kidney or percutaneous primary renal artery vascular embolization intervention.