The removal of epididymis in men may affect male fertility, and patients need to pay more attention to post-operative care. The epididymis in men mainly includes the output tubules and epididymal ducts, which have the functions of temporary storage of semen and promotion of sperm maturation. For patients with epididymal tumors, it may be necessary to remove the epididymis, which will cut off the sperm pathway, thus affecting the fertility of the patient. However, men can still maintain normal sexual function. Meanwhile, patients need to closely monitor their condition after surgery, take strict bed rest, and actively regulate their emotions to maintain a good mindset. For patients with epididymal tuberculosis, they need to adhere to the anti-tuberculosis treatment for more than 6 months after the operation, and for patients with chronic epididymitis, they need to use antimicrobial drugs as prescribed by the doctor after the operation to prevent infection. And patients also need to remove the drainage in 24~48 hours after the operation, and remove the sutures in 5~7 days after the operation. It is recommended that patients strictly follow the doctor’s instructions for epididymectomy, do not worry too much, and consume easy-to-digest, nutritious food 6 hours after the operation.