Dry and cracked soles of the feet may be caused by physiological factors, such as environmental dryness, etc.; it may also be caused by pathological factors, such as tinea pedis and eczema. Treatment includes daily care and medication. 1. Physiological factors: If the soles of the feet are peeling and cracking due to a dry environment or frequent use of alkaline detergents, you need to carry out daily care, drink more water, and apply local moisturizers such as urea cream. 2. Pathologic factors: (1) Tinea pedis: the disease is caused by fungal infection, in which keratinized tinea pedis can lead to dryness, flaking and cracking on the soles of the feet, etc. Antifungal drugs such as clotrimazole cream and terbinafine cream can be used under the guidance of a doctor, as well as keratin-exfoliating drugs, such as salicylic acid ointment, can also be applied. (2) Eczema: this disease is a chronic inflammatory skin disease caused by a variety of internal and external causes. Among them, chronic eczema can appear on the soles of the feet with symptoms such as flaking, dryness and cracking. Strong glucocorticoid creams such as halometasone cream can be used externally, and antihistamines such as cetirizine and loratadine can be taken orally. In the course of treatment, it is necessary to strictly comply with the doctor’s instructions, safe and reasonable use of drugs, and at the same time pay attention to good daily care of the soles of the feet.