Squamous cell carcinoma refers to a type of pathology that is malignant and the prognosis is based on the specific location and stage of the patient’s tumor. For early stage patients, there is a higher chance of radical treatment through surgery. For middle and late stage squamous cell carcinoma patients, comprehensive treatment such as chemotherapy, radiotherapy and targeted drug therapy can improve patients’ quality of life and prolong their survival time. Squamous cell carcinoma of skin is a kind of malignant tumor originated from epidermis or appendage keratinocytes, which mainly occurs in the elderly, and preferably occurs in scalp, face, back of hand and other exposed areas, with relatively low metastasis and malignancy, and the prognosis is closely related to the degree of differentiation of the tumor, its size, location, and whether it is metastatic or not. Generally, low-differentiated squamous skin cancers are more malignant and metastasis will occur in early stage. For in situ squamous cell carcinoma with small skin lesions, it can generally be successfully cured by surgical excision and has a better prognosis, while if it develops faster or metastasizes, the prognosis is worse. It is believed that ten-year survival rate of squamous skin cancer patients with localized lymph node metastasis is <20%, while ten-year survival rate of those with distant metastasis is <10%. Therefore, early detection, early diagnosis and early treatment is the key.