The prognosis of severe hepatitis is mainly judged from several aspects: the first is the clinical manifestations, such as whether there is improvement in the gastrointestinal symptoms, whether there is improvement in the symptoms of poor appetite, weakness and abdominal distension, whether there is improvement in the related complications such as peritonitis or hepatic encephalopathy. The second is the laboratory index, whether the liver function and coagulation function have improved, especially the prothrombin activity, whether there is a trend of increase in prothrombin activity after related treatment. If these two indicators are in a good direction, the prognosis of heavy hepatitis may be better. If, after active treatment, the patient’s clinical symptoms are still very heavy, with poor nasal function, weakness, anorexia, and a progressive decrease in prothrombin activity, with other infections, such as abdominal infection, lung infection and other complications, the prognosis may be poor.