The treatment of a blister inside the eyelid varies depending on the cause of its formation. If it is caused by chalazion, it can be treated by hot compresses, surgery, etc. If it is caused by granuloma, it can be treated by using antibiotic drops, etc. Bubbles inside the eyelids can be caused by a variety of reasons, the more common are chalazion and granuloma. Chalazion is caused by too greasy diet, too little face washing, chronic conjunctivitis, etc., resulting in the blockage of the opening of the blepharoplasty gland, the gland’s secretions are retained in the eyelid, causing chronic irritation to the surrounding tissues, which can be promoted through hot compresses, local injection of glucocorticoids and other methods to promote its absorption, but also through surgical excision for treatment. Macrocephaly is mainly caused by infection of the blepharoplasty gland or eyelash follicle, and can be treated with antibiotic eye drops, such as levofloxacin eye drops, tobramycin eye drops, and so on. The medication should be used according to the doctor’s prescription. It is recommended that patients go to the hospital for examination to clarify the cause of the disease and timely treatment to avoid aggravation of the condition.