Closed mouth refers to closed pimples in medicine, and closed pimples on cheeks can be removed by general treatment, medication and physical therapy. 1. General treatment: For patients with closed pimples on the cheeks, they need to pay attention to facial cleanliness and hygiene, and avoid staying up late and living an irregular life. You can eat more fresh vegetables and fruits. 2. Drug treatment: patients can apply retinoic acid drugs, such as adapalene gel, tazarotene gel, etc., can play a role in reducing the inflammatory response and dissolve keratin, etc. It should be noted that the drug has the risk of teratogenicity. Patients can also use topical benzoyl peroxide, azelaic acid and other drugs to help inhibit Propionibacterium acnes. 3. Physical therapy: For closed pimples, red and blue light irradiation can also be used as an adjunctive treatment, which can help the lesions subside, kill germs and improve the keratinization of sebaceous gland ducts. There are many ways to get rid of closed pimples on the face, and it is recommended that patients go to a regular hospital and cooperate with the doctor for standardized treatment. The medication should be used in accordance with the doctor’s instructions.