Recurrent fever for 1 year, lymph node biopsy suggests EBV-associated lymphadenopathy, how should I treat it? Do I need treatment? The incidence of EBV-associated T-cell lymphoproliferative disease (EBV-TLPD) is low and has not been systematically described by Uptodate. EBV-TLPD has a poor prognosis and can progress to aggressive NK/T-cell lymphoma (ANKL) [1]. The real-time update book of NCBI suggests that EBV-TLPD can be treated by therapeutic regimens of hormones, cyclosporine and etoposide, but some patients will relapse and require multiple doses of chemotherapy, and many patients will require allogeneic transplantation for cure [2][3][4]. NK/T lymphoma is ineffective with anthracycline-based RCHOP chemotherapy and is basically treated with SMILE, P-GEMOX and DDGP regimens, with only some patients benefiting from AspaMetDex. Reviews of EBV-TLPD all agree that its inclusion of diseases such as CAEBV, phagocytosis and NK/T-cell lymphoma is estimated to cause lymphatic value-added disease in patients is only a transition and patients can progress to phagocytosis or lymphoma at any time, if the patient is only chronically febrile, only CAEBV can be diagnosed [5], while the best treatment for EBV-TLPD is unknown. (The 1988 criteria for CAEBV, which are constantly challenged, and which previously must have been onset for 6 months and must be positive for EBV antibodies, are now considered to be an undefined disease that can be diagnosed with persistent EBV infection and symptoms [6]). Hemophilia may also be diagnosed if the patient is febrile, has elevated ferritin, has a 2-series abnormality in the blood picture (none at the time of initial admission, which has now progressed), and if there is a congenital HLH gene, or decreased NK activity and elevated sCD25. In summary, it is recommended that this patient have a second-generation sequencing, which is only 8500, and may later guide the treatment and prognosis. There is no recognized best treatment for the patient, only clinical trials. Personally, I suggest that the treatment reference is hemophagia, or if more aggressive, NK/T lymphoma.