The treatment of depressive mania includes medication and psychotherapy. Medication mainly involves the use of mood stabilizers or antipsychotic drugs, and mood stabilizers are usually lithium carbonate, sodium valproate, carbamazepine, and so on. Antipsychotic drugs are usually olanzapine, quetiapine, risperidone, aripiprazole and so on. These drugs not only can have obvious effect on the symptoms of mania, but also can relieve the patient’s depression. If, on the basis of the application of these two drugs, the patient’s depressed mood is still very obvious, or even has self-injurious or suicidal behavior, a small amount of antidepressants can be used with caution, and antidepressants with less transmanic effect, such as bupropion and fluoxetine, can be chosen. In addition, psychotherapy can also be carried out, such as cognitive behavioral therapy, psychoanalysis, etc., you can let the patient to write cognitive behavioral diary, record their mood every day, no matter whether it is a depressed mood, or manic mood is to feel good mood. Then help patients to understand and recognize their mood changes and causes of mood changes, and then slowly learn to adjust their mood, not to let the mood ups and downs.