Whether urine specific gravity affects urine microalbumin depends mainly on the cause of the abnormality. If the cause is physiological, such as drinking a lot of water, the specific gravity of urine is abnormal, usually has no special effect; if the cause is pathologic, such as nephrotic syndrome, chronic glomerulonephritis and other causes of abnormal specific gravity of urine, it may affect the urine microalbumin.
The reference value of urine specific gravity for normal adults is 1.015～1.025, which is related to the content and solubility of water, salts and organic matter in urine, and positively proportional to the concentration of urinary solutes (salts such as sodium chloride, urea and creatinine), and is affected by the age of the patient, diet and urine volume, etc. In pathological conditions, it is affected by the components of urinary glucose, urinary proteins, and cellular and tubular patterns.
Urinary microalbumin is usually not affected if the cause is physiologic, such as an abnormal urine specific gravity due to heavy drinking. If pathological causes such as nephrotic syndrome, chronic glomerulonephritis, acute glomerulonephritis and so on lead to abnormal urine specific gravity, then it may affect the urine microalbumin.
If patients find abnormal urine specific gravity or urine microalbumin, it is recommended to go to regular hospitals in a timely manner, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.